For folks unfamiliar with the intrepid Ms Blake, she's the star of a series of pulp novels. They're a mix of hardboiled detective story, romance novel, and monster horror, in a way that's surprisingly more witty than goofy. As the series progresses, the prose improves but the mix of tones becomes more awkward. Strongly recommended for folks charmed by the idea, strongly not for civilians.
Usually, adaptations from other media to comics are a waste of time. The only exceptions I can think of off hand is Bill Sienkiewicz' surreal “best of” Moby Dick and Chester Brown's scary Gospel of Matthew.
I've flipped through the first issue of the Anita Blake adaptation, and it really stinks. So you know. Lisa Fortune explains that this is because the style of the art is totally inappropriate to the story.